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Patients with elevated baseline inflammatory markers (CRP, IL-6) or copper metabolism disorders may face higher risk of adverse reactions

Compared to adenomas (50%), moesin is predominantly expressed in the stroma (inflammatory cells and fibroblasts) of carcinomas (89.1%)

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Berberine can cause its own GI side effects, including nausea and diarrhea

As adults are more susceptible to hyperammonemia, emergent hemodialysis is mandatory before referral to a reference center if ammonia levels are above 200 mol/l as the risk of cerebral edema is then above 55%